Matthew Might Selected Research

Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase

10/2021	Generation of two gene corrected human isogenic iPSC lines (NCATS-CL6104 and NCATS-CL6105) from a patient line (NCATS-CL6103) carrying a homozygous p.R401X mutation in the NGLY1 gene using CRISPR/Cas9.
1/2019	Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p.Q208X and p.G310G mutations in the NGLY1 gene.
1/2018	Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches.
1/2017	Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-β-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease.

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Matthew Might Research Topics

Disease

4	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 01/2017
4	NGLY1 deficiency 10/2021 - 01/2017
4	COVID-19 07/2021 - 01/2020
1	Brain Diseases (Brain Disorder) 01/2022
1	Rare Diseases (Rare Disease) 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 07/2021
1	Infections 07/2021
1	Hypertension (High Blood Pressure) 07/2021
1	Disease Progression 01/2021
1	Epilepsy (Aura) 01/2018
1	Hyperkinesis 01/2017
1	Seizures (Absence Seizure) 01/2017
1	Liver Diseases (Liver Disease) 01/2017

Drug/Important Bio-Agent (IBA)

4	Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseIBA 10/2021 - 01/2017
2	Metformin (Glucophage)FDA LinkGeneric 07/2020 - 01/2020
2	Pharmaceutical PreparationsIBA 01/2019 - 01/2018
1	trkB ReceptorIBA 01/2022
1	Interferon Regulatory Factor-2 (Interferon Regulatory Factor 2)IBA 01/2022
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	remdesivirIBA 07/2021
1	tocophersolanIBA 07/2021
1	Antiviral Agents (Antivirals)IBA 07/2021
1	Tocopherols (Tocopherol)IBA 07/2021
1	Peptide Hydrolases (Proteases)FDA Link 07/2021
1	Androgen Receptors (Androgen Receptor)IBA 07/2021
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 07/2021
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 07/2021
1	acetyl- 2- naphthylalanyl- 3- chlorophenylalanyl- 1- oxohexadecyl- seryl- 4- aminophenylalanyl(hydroorotyl)- 4- aminophenylalanyl(carbamoyl)- leucyl- ILys- prolyl- alaninamide FDA Link 07/2021
1	AndrogensIBA 07/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Acetylglucosaminidase (NAGase)IBA 01/2017
1	Proton Pump InhibitorsIBA 01/2017

Therapy/Procedure

4	Therapeutics 01/2022 - 01/2017
1	Precision Medicine 01/2022
1	Artificial Respiration (Mechanical Ventilation) 07/2021